Monday, June 14, 2021

New Cancer diagnosis

Some resources after you or a family member receive a cancer diagnosis.    Educate yourself.  Ask lots of questions.  Discuss everything with your doctor.  Implement what you feel is right.  Trust your instinct.   Above all support your body with hydration, rest, nutrition, detox, and regular bowel movements.  Nothing on this page should go against what your doctors are trying to achieve, instead it should complement and support your journey.

If your child has been diagnosed with cancer, please read this post first: New diagnosis leukemia: how family and friends can help
For my friend Serena, fellow warrior mom, who visits and supports so many families at Arkansas Children's Hospital after spending a lengthy amount of time there with her daughter.   She is the first to make sure parents know some of the basics helpful websites such as these
 Kick cancer movement - register for the free kit of natural products to support your child through this journey.  You will pay for shipping of $9.95.  One of the many products is worth more than that. 

NEGU (Never Ever Give Up)  - sign up for Joy Jars to be sent monthly and typically some extra surprises throughout the year for your child and siblings.  It has fun little toys that bring smiles to children every time they get one in the mail.  The hospital should have the first jar there for you. 

Strong Little Souls - will send care packages to child and siblings

Hopecam - supplies children with a tablet, chromebook, or IPAD for free. 

Healios - you will receive a container of Healios for the cost of shipping only at $14.99  for a child with a cancer diagnosis.  This is extremely helpful for mouth/gastrointestinal ulcers that commonly occur with chemotherapy.   I recommend getting this and having it before you need it.  Our doctors support using in, please discuss with your doctor. 

Sara's Smiles  - provides art supplies to allow the children to express themselves.  You can also ask your social worker for them. Request a kit to be sent.

Lost Cabins of Petit Jean in Arkansas  The owner Mark hosts a free weekend retreat just for families dealing with childhood cancer.  He does this once a year and provides some of the meals.   You have to call and be placed on his list.  It was a wonderful experience to get together with other families while staying in the beautiful cabins. 

Make A Wish  - a wonderful organization that provides a child's wish.  For us, they gave my daughter a camper so we could travel and remain isolated since our treatment was over 2 years.  You should contact them early since sometimes it takes awhile to get to you.  

Roc Solid Foundation - incredible organization that will provide you with a "ready bag" if your hospital does not have one.  These bags contain everything you need for a quick hospital stay or long days at the clinic that includes a tablet, charging cords, blankets, and more. .   They also will send your child (under 10 years old) a free playground playset.  See website for details and contact them as soon as possible to get these items. 
 Princess Nora's Warriors - request information, prayers, or assistance. Out of Hot Springs, AR.


The rest of this blog is my personal opinion of websites and books that I found helpful.

Books to read: (amazon or

               Metabolic Approach to Cancer - recommended to me by a Dr, I found it very interesting.  Helps you analyze your terrain and where improvements could be made.   A great book to start with.  Author Dr Nasha Winters has numerous youtube videos discussing.

                Keto for Cancer - we had genetic testing done (Nutritional Genome -see below), which determined keto was not an option for us, but many have recommended it for cancer.   We chose to support with extreme nutrition as much as possible.

                Chris Beat Cancer - good nutritional advice in this book for the entire family.   He beat cancer in his 20's and dedicates his time to educating others.  Easy to follow and implement.  Focuses on high antioxidant anti-inflammatory nutrition.

                Max Lucado's workbook Experiencing the Heart of Jesus.  This was sent by a sweet friend who knew what I needed before I did.  Find an outlet that nourishes your soul and focuses on the positive.  I was given a small notebook to write down my blessings each day, instead I used it write bible verses about healing, faith, miracles, or encouraging words that helped me.

                 Naturpathic Oncology -  this book was recommended to me.  If you give supplements, you can check to see if they are helpful or harmful for the current treatment they are receiving AND always discuss with your doctor.  You can also look up recommended supplements for various cancer diagnoses.



The Stern Method - a family whose son had cancer.   They cleaned up their entire home and lifestyle.  Tons of information about naturally supporting someone who has cancer.  They have a resource page that lists by brand what has worked for them.   He is preparing a course to walk anyone through a cancer diagnosis.  I really like this website and family.

Season Johnson - a mom whose son had ALL/leukemia and thrived through the 3 years of treatment using diet, lifestyle changes, and essential oils. Her website and FB are a wealth of information.   She is also a nutrition/health coach. If interested in essential oils, she shares what oils she used for her son's immune system, nausea, detox, and more.  They will also answer questions within hours if you ask. She also founded a website called KickcancER which also sends a free starter kit to families whose child has been diagnosed with cancer.  Here is her recipe for essential oil blends specifically related to cancer.

Thrive through Cancer podcast - also by Season Johnson

Zuzas Way Integrative Care - warrior mom also that is also a medical provider/integrative oncologist , she shares what she has learned.  Also has a FB page.   Promotes keto diet, nutrition, and supplements to support the body.   She was instrumental in advising us what supplements to use to support our daughter during each phase of treatment and to help with side effects of all the meds.

Dr Nasha - author of Metabolic Approach to Cancer, shares good information to assess your terrain.  Also promotes keto type diet. Also on website to sell premade organic shake pouches.

The Truth About Cancer -  Most detailed information addressing everything cancer.  There is a book with the same name.

Chris Beat Cancer - website and book,  a lot of good nutritional advice from a cancer survivor with this anti-inflammatory diet.   He hosts a free Square One program for free once a year, but you can buy the program anytime.  I bought the DVD set new on ebay for $20.  If you are local to Little Rock, you are welcome to borrow mine.  Extremely helpful information about what nutrition can do to help someone through a cancer journey.  Chris also wrote a book with daily inspirations to encourage and educate you one day at a time called Beat Cancer Daily.  I really enjoyed it.   Also a cookbook with cancer fighter recipes called Beat Cancer Kitchen

Nutrition Facts - Dr Michael Gregor has nutrition information on numerous health topics, not specific to cancer, but founder of the "daily dozen" to health promote family wellness.   Use the search option to find topics related to you.  He also has a book called How Not to Die, which breaks down different cancers and diseases and what scientific data supports the best nutrition for it.

Wellness Mama - good advice about cleaning up diet and home as well as wholesome easy recipes from a regular mom like us.  Not specifically cancer centered, but a good start to detox your home. 

Max Love Connect - a website, FB page, and app that connects you with like minded cancer parents/patients who want to live a healthier life.  You can ask questions or just read and learn.   Great information on nutrition.

Eat To Beat Cancer - MD website about healing with nutrition.   Lots of recipes.  Also has a book by same name with great information.

Believe Big - good website with information about various cancer therapies and  they will help you find an integrative practitioner if you want.  Integrative practitioners can guide you through chemotherapy with various supplements and therapies to support the body.  They work with the conventional therapies/chemo and ensure you do not give something that would counteract the medications you are receiving.  

Believe Big Radio is a weekly podcast developed to help you find answers about integrative cancer treatments and prevention. In each episode, we will take a deep dive into your healing with health experts, integrative practitioners, biblical faith leaders and cancer thrivers from around the globe.


*  Be prepared.   Stock up on food, juicing materials, supplements, etc... before your treatments start.  Think  like you will be exhausted and what will help you the most.  Find somewhere that delivers to you.  Thrive Market delivers nationwide.  We are fortunate to have Whole Foods close enough to deliver.  Try these out before treatment begins.   Can you order Kroger online and have family pick it up curbside for you?  Think detox, hydrate, regular bowel movements, nutrition, and rest as your top priorities.  Keep moving, even if it is a gentle walk as your energy allows.  I bought a small automatic pedal bike for my daughter.  I strapped her feet in and it passively moved her legs as if she were riding a bike just to keep her active.  She was willing, but Vincristine made her legs uncooperative and weak and unable to walk.

* Consider learning to juice.   Make ahead and freeze or designate someone to help with this.   Here is my favorite recipe:  Season Johnson's green juice .  Chris Wark has a good post explaining how and why here.  If you can't juice or don't have the time or energy, then consider a low sugar juice like the Farmer's Juice which is keto friendly and packed with organic dense nutrition.  Your goal is to get as many nutrients in each day as you can. Best juicer is the one you will actually use.  My personal favorite is the Nama Juicer because you can put everything in the top container and walk away.  It is expensive, but typically family members are wanting to help and this would certainly help you get condensed nutrition in your child in a shorter amount of time. Be sure to clean your fruits/vegetables very well since the immune system is compromised on chemotherapy. (Discuss with nutritionist/doctor)

*  Smoothies - my family drinks one each day.   Container 1 has flax seeds, sunflower seeds, sesame seeds, apricot seeds, and pumpkin seeds ground into a fine powder using a coffee grinder and all mixed together. Container 2 has spirulena, matcha, cranberry powder, acai, beet powder, and a mushroom mixture all ground together and in one container.  I buy theses plastic cups with lids and straws so they can be made ahead and placed in the freezer for a week at a time.  I put one tablespoon from each container into each cup then add an approximate 1/4 cup of each: avocado, raspberries, blueberries, dark cherries, and mango.  You can also add cilantro or broccoli sprouts to increase the nutrition.  Just add coconut water or almond milk in the morning and spin them up.   Easy to make ahead.  


* B complex supplement - most people need a good B-complex, but discuss with your doctor.  It needs to be stopped around chemotherapy days using methotrexate.   According to the book Naturpathic Oncology, several other chemotherapy drugs do not go well with B12, so be sure to check.

*  Check Vitamin D levels.  Low levels associated with many diseases, including cancer.   Find out now if you need to begin supplementing.   Optimal levels 60 or above.

* Nutritional genome - a genetic testing company that offers important and fascinating information.   This is how we found out a keto type diet was not right for us  Cost was $299, but worth it.   It told me that my daughter was not a good responder to the ketogenic diet.   It provides: 

  • Personalized grocery list
  • Recommended blood work
  • Toxins / foods to avoid
  • Genetic strengths & weaknesses recap
  • 100 clinically relevant genes (151 SNPs) for a whole body approach to wellness
  • 8 targeted reports profiling Digestion, Energy, Hormones, Stress & Cognitive Performance, Inflammation & Longevity, DNA Repair, Detoxification, and Athletic Performance

 * Plan ahead for hospital stays.  For us, that meant a "go bag" packed with her favorite pillowcase, pajamas, books, toys, filtered water pitcher, EMF blocking blanket, blue blocker glasses so as not to interfere with natural melatonin build up each night, sound machine/Wholetones, flashlight for me so I don't wake her up when I stay up and I used as soon as the nurse walked in so she didn't turn on any lights, tape to cover machine lights or to hold curtains to cover hall windows, condensed food packets/healthy snacks like these that provide healthy fats/proteins:  Super Fat keto pouches , made ahead frozen juiced vegetables/fruit, fresh fruits and vegetables. 

*  Consider CBD oil - I wasn't a fan until my daughter was diagnosed with cancer and had so much pain.   Do your research,,talk to your doctor, and see if it is an option for you.   

* Haelen - a fermented drink.   Call Jordan and ask how it might help you.  It is not cheap, but we were told no probiotics while "counts" were low, but fermented items were ok. This product has an impressive history. Discount for military.

* Healios - a product to have at home before you need it.  It helps with oral mucositis (chemo mouth ulcers).  Developed by an oncologist.  If it is a child who has the cancer, they will give you the first bottle for shipping costs only.   Also buy chemo soft toothbrushes.  You can also rinse with baking soda and water.  Gastrazyme is made from raw cabbage and was recommended for us and helped tremendously.

* Bone broth - full of healing nutrients, especially for the gut.  Make your own or buy these packets to add to warm water and drink each day.  They also make a bone broth protein powder you could make a smoothie with.   I cook noodles in broth and add the powder to almost everything to make every bite count.

* Detox - epsom salt baths, infared sauna, BioMat, sweating, movement/rebounding, hydration

* A friend recommended Transfer Factor Plus to support the immune system.  My entire family takes transfer factors.    

Good articles:

Dr Jockers Top Cancer Stem Cell Killing Nutrients - a must read

Glutathione is extremely important and gets depleted quickly.  Read this to learn more.

Stimulating the lymphatic system is a must, read why and how here.  

These are just a few things to get you thinking and prepared.  Everything may not be right for you, but you need to know there are options. We don't do all of it, but we do the best we can and what is appropriate for us.  Once you go down the rabbit hole, you will find much more.   This was put together quickly to help a friend out.  I will edit and add to it at a later date.  

Remember Proverbs 23:7 "As a man thinks, so he is".  Keep your thoughts positive.  Pray and stay encouraged.  



Disclaimer:  This is informational only and is not a substitute for medical advice.  Discuss with your doctor any interventions you are considering.  You can also ask to discuss supplements with the oncology pharmacist, like we did, to ensure the supplements did not interfere with the chemotherapy.


Monday, March 1, 2021

How friends & family can help when you find yourself at the hospital with a child

 On January 8, 2021, Presley was diagnosed with leukemia (ALL).  She had never really been ill and or even been on antibiotics, so we were not prepared.  She had only been sick around 36 hours when we found ourselves admitted to the hospital for an indefinite amount of time.  We were very blessed to have family close by and friends within the Down syndrome community who jumped into action while our heads were still spinning in disbelief.   

Now, seven weeks later, I wanted to put into writing some of the things that I found helpful in hopes that maybe it will help another family when everyone asks "how can I help" or "what do you need"?   At the time, I didn't know what I needed, but thankfully I had a village who did.

My amazing friend Tricia began researching.  She juiced organic beets and carrots for Presley to begin drinking while still in the hospital.  She brought me a homemade smoothie every morning to help me get through the day.   She brought a variety of applesauces, protein bars, Lara bars, salads, nuts, coconut treats, yogurts, fresh fruit and vegetables and bottled water. The hospital did not provide meals for the parents, so she was taking care of me when I didn't. 

She also washed a stuffed animal and covered it with essential oils, as well as sending a variety of oils to me.  We have always used essential oils, but it wasn't something I grabbed when headed to the hospital.  I hope everyone has a Tricia in your tribe.  Thank you my friend. 

Prayer chains were good for my soul as churches and people around the entire globe began praying for my sweet daughter.  Upon discharge, I stopped by the outpatient pharmacy in the hospital and the pharmacist told me she had been praying for Presley every day because her name was sent out by her church.   I didn't know her or recognize her church.  Prayers work miracles.  

Listed below are ideas for family and friends of children who find themselves in the hospital.  Everyone wants to help, but often the parent is just too overwhelmed to answer calls, texts, or messages, so maybe this can provide some guidance about what we found fun and useful.


Things we received

Lots of balloons and stuffed animals brightened up the dreary hospital room, especially since we didn't face the outside world directly.  It brought big smiles every time the clerk walked in with a surprise.   We called her the "gift fairy", but she wasn't as amused by it as we were and told us we were wearing her out. Presley used some of the stuffed animals to cover her port that was placed in her left upper chest.  She would sleep with them there to make sure no one touched the area.  That cheer was transferred home as it filled our living room.   It was a strong visual reminder of the love everyone had for our daughter. 


Joy Jars - go to to learn about this jars that are jam packed with fun toys, activities, games and hats sorted by age.   Read the story how one girl named Jesse wanted to make a difference.   Our nurse brought us this, then we signed big sis up too and they sent another after our discharge.   These are fun ways to entertain.   Ask the staff, I bet they have them!


Beads of Courage - the nurse gave Presley a bead for every accomplishment she made.  One for surgery for her port, another for first chemo and a chart to explain it.  We took it home to put together on a necklace with big sis.   The nurse said one teenager wore it on her graduation day.  Ask the staff about it or check out their website.

Rapunzel Wig hat - this was given to us by the child life specialist. They had several princess wigs, but Presley loves Rapunzel. 

Barbie  doll - with no hair and 2 wigs -talk to the child life specialist and see what they have

Big 18" doll with no hair telling a story of recovering from Cancer.   Super sweet gift from a friend.  


Hats or super soft head covers in anticipation of hair loss.  We got a variety of hats to give her a choice.  Some were handmade, some from Amazon and some on Etsy.

Superhero Training book - this is a very special given to us by my new friend Jackie at Rainbow Blankets.  It belonged to her son.   It turns the hospital into a world of training opportunities.   I showed it to our Child Life specialist and she was going to order some.  Read here to learn more about it. 

Tiny Superheroes cape -  one of Presley's Special Olympics swim coaches raised money to get Presley one of these special capes and it went so well that they were able to pay for several other children's capes too. 

Draw It Out book  by Art With Heart to help kids overcome adversity.   I got this from the Child Life Specialist for big sis who loves to draw.  It encourages her to express her feelings through drawing.  "When ink touches paper, the heart says what the words cannot".

Sibling:    "What About Me? When Brothers and Sisters Get Sick"  The Child Life Specialist gave us this when I asked what they had for siblings.  

Because Someone I Love Has Cancer book by the American Cancer Society - Kids activity book that involves drawing and answering questions

Sparkly house shoes for Presley. They had panda faces and she loved them. 

Baby doll with bottle that gave Presley something to feed and play with.   It also gave us something to show procedures on if needed.

DVD player with movies - we happened to have an old one at home and it hooked up nicely at the hospital to watch all of our favorites from home.  Another mom suggested a Fire stick to have for movies and Netflix. 

Handmade masks for entire family  - will need many to allow dropping on the floor, losing them, and washing them each time they are worn

Drawing supplies or kit for child and sibling (like a pretty notebook and markers)

Coloring books w/crayons or mess free markers & coloring pad or Water Wow books

Sticker face games - lets you put eyes, ears, etc...on a blank face or animal.  Presley loves these. Keeps the hand going with fine motor movements.  Here is a search on amazon with dozens of fun ideas.

Colored rubber bracelets that said her name or special color for cancer to let Presley and Payton to give out to family and friends.  She was also given stretchy, cloth bracelets with horses on them.  She gets a different one each week with an inspirational quote card attached. 

Crafts kits  -we received a flower crown and fairy lantern one for both girls to do

Lotions and chapstick made with basic natural ingredients to combat the extreme dryness that comes with the medications.  Epsom salt to soothe those exhausted little muscles. 

Bubbles - fun, but also encourages the child to exercise their lungs while laying around more

IPAD - we didn't use electronics much before this, but knew we needed a way to keep entertained while indoors more.  Tricia brought one up immediately and family members got together and purchased a really nice, purple one for them

Board games - age appropriate, something we love to do at home before this happened

T-shirts - we received a christian shirt and one with a chicken on it.  This are 2 things dear to Presley, so she loved wearing those in the hospital and telling everyone about them.  Plus, it got us out of the hospital gown for awhile.

Port Access shirts -  sometimes called "Chemotherapy" or "adaptive clothing", but can be difficult to find.  There is one awesome lady named Laura Frank Pursglove, whose grandson has cancer, so she and some friends began converting T-shirts into port accessible shirts by adding snaps.   They do this out of generosity at no charge.  She has given me permission to put her name on here to contact via Facebook.  Find her here.

Cards - sometimes the hospitals have e-cards you can fill out online and they will print off and take to the child.  The girls loved getting real cards with stickers in them addressed to each of them after we got home.

Books -  Presley loves dolls, fairies, unicorns, and anything girlie.  Books are fun and easy for her.  She loves reading together, so always a great gift for kids.  Look at the Step Into Reading books for younger kids in their favorite topics.

Music box - she was given a small wooden music box that plays "Jesus Loves Me" when you turn the handle.   We carry it to each appointment and play with it.

Zoom call with a Princess - we had a kind friend who had beat Cancer herself purchase this for the girls after we got home. They chose Rapunzel and the girls absolutely loved it.  She read a book, sang to them, then just talked and laughed with them.  A very unique gift to give a child while staying home.

Blankets - so many beautiful, fun, creative, and handmade blankets!   I don't think you can have too many.   We used them in the bed, in the chairs, on the floor, in the bean bags, in the chair, in the clinic.  I loved how people used their talents of sewing and quilting to bring joy to my daughters.   Many times, they were given to both of my daughters, which made Payton feel special too.   

Kensi's Rainbow Blankets -Please buy someone you love one of these adorable blankets.  A sweet little girl named Kensi sells these blankets to raise money for pediatric cancer research in honor of her little brother who had brain cancer.  A dear friend gifted us one and introduced us to the mom of this sweet girl.  A beautiful example of kindness. 


Pictures from her friends:

    * Her instructor where she takes horse riding lessons, "Mr Ron", made a sign for Presley and put it on her favorite horse.  He also sent many videos while he walked around the stables and named all the horses, chickens, and dogs she was used to seeing.  She loved seeing this.

 May be an image of horse

    *  Her taekwondo instructors sent her and big sis a package of all things taekwondo that included hats, wristbands, pink belt hairbands, and more.  There was also a big poster that defined what courage was. 

    *  Big sis Payton made a video when she fed the animals and made sure to include her favorite pet chicken "Rainbow" everyday while we were in the hospital.  Now at home, she brings it to the window each morning to say hello. 

    *  Presley's previous cheer team made a video of all the kids and instructors wearing her favorite color purple and saying words of inspiration, then ,set it to music.  It was beautiful. 

    *  Handmade cards from their best friend and pen pals that kept coming even after we made it home were priceless and they were excited for mail each day.  

Child Life Specialist or Social Worker - they brought toys and games by each day to use.   They also offered books for big sister when we got home to help her understand and talk about what was going on and how things were going to change for awhile.  They also sent for music therapy, and a therapist came by with a cart full of instruments and they played songs together.   It was Presley's favorite thing in the hospital, so ask for it.   There are also many resources to assist financially.  Lean on these specialists, they will find a way to make your child feel more comfortable about what is going on.

Things I ordered in anticipation of going home or soon after we got home:

Waterproof pads ("Chux") - it was very painful to move for awhile, so having these under her saved us from moving her excessively when an accident occurred, and it will from all the IV fluids they are receiving to stay hydrated and keep the body flushed out.

Waterproof reusable pads that are soft and washable. Can go on the couch, beanbag, or bed if needed. I also bought the larger ones.

Extra set of sheets for her bed to keep washed and ready

Goodnite Diapers - accidents are going to happen at night

Castor oil pack - to help with constipaton, detox, lymph stimulation

Silcone straws - needs to be flexible as you offer fluids often at home while she was lying down.   I cut some of them shorter to fit in the medicine cups too.

Passive range of motion small pedal exerciser:   I ordered this to get those little legs moving again once she felt better.  It is motorized and can start very slow and gradually increase.  It has a 15 minute timer.   It can be used for legs or arms.   For $139, I thought it was great.  Initially, I had to hold her legs straight so they didn't fall to the side due to the muscle wasting she experienced so quickly.  Within 2 weeks, she could do this by herself.  I sit beside her still and do not recommend leaving them unattended.  Bonus, there is also a cool study about DS and the benefits of assisted cycling therapy here.

Walker/wheelchair - a friend let us borrow a 4 point walker with a seat and brakes while waiting for the large stroller type wheelchair to come in.  This had a seat that stored her books and anything we might need to keep near by.  Presley called it her "carriage".  It is very common for children to stop walking the first month during induction due to the Vincristine causing issues with reflexes, neuropathy, and muscle loss.   I suggest ordering the stroller/wheelchair early, even though they may still be walking fine, the fatigue will be there for awhile and it took a few weeks for the stroller to come in.  This gives me a way to get Presley outside on nice days and move from room to room more easily.  (Disclaimer:  the walker we used had a sticker stating not to use it for transportation, supposed to be used as a chair for resting only) This is a picture of the one we ordered through insurance:


Therapeutic massager/vibration - I already owned this one, and it has been invaluable.  I use it on Presley's feet and legs each morning for the neuropathy, then on her abdomen to fight the constipation caused by the meds and inactivity, to encourage lymphatic draining that is typically stimulated by daily movement, and to her back and chest to help prevent fluid from building up while lying down so much.

Pado pure wave CM7 - Massage Customs | Best Therapists in ...Inflatble mattress - we already had one.  Presley wasn't comfortable sitting upright on the couch after so many spinal taps and was basically too weak to remain upright long.  She would ask to lay down.  We put an inflatable mattress in the living room to keep her moving around the house and engaged with us instead of just laying in her bed room.  

Soft, cushioned toilet seat - sounds crazy, but one of the major side effects of Vincristine is constipation.   We spent a lot of time trying to overcome this.  Presley's legs were too weak to even hold her legs on a small stool or the squatty potty stool, so I took extra bathroom rugs and towels and made them tall enough for her feet to rest on, but they would discolor from the position on the seat, so this cushioned seat was extremely helpful.  Costs $20 at Lowe's.  

Fruit & Veggie Wash - they warn you about unwanted germs when consuming anything fresh because the immune system will stay so suppressed.  Tricia again for the win, she brought me some Young Living Thieves Fruit & Veg wash.  We didn't want to stop eating fresh, so this helped out.   It also helps out to soak the fruits/vegs before juicing them. 

Soft tooth brush - you can google "chemo toothbrush" and find a variety.  When you child's platelets are very low, you will see easy bruising and possibly bleeding when you brush their teeth, so a soft toothbrush is recommended.  Also later, a side effect called mucositis can occur which causes sores in the mouth so buy multiple and you can change out often.   Another mom said she uses baby toothbrushes because they were so gentle.

Large Bean Bags - again, to keep Presley from just staying still in bed.  The bean bag allowed her to recline between a sitting and supine position but completely supported.  It could also easily be moved to different rooms.

Did you know you can save your child's own hair to make a WIG out of it????  I wish we had know this because Presley had the most beautiful long blond hair, she called it her "Rapunzel hair".   Look at this non profit called Crowns of Courage.    You can also just apply for one of the halo wigs too.   Looks like a great place to donate hair as well, but check the website to see if they are accepting at this time.


Things for Mom, Dad, parents, grandparents, or caregiver:

Extra pajamas for days you just don't get dressed, and houseshoes while at the hospital  (thanks Sis)

Chamomile w/lavender or other teas for stress, coffee if they are coffee drinkers

Essential oils with device to wear (bracelet, necklace) - I found them calming for me

Journal - I received a blank journal and began writing favorite bible verses in it that encouraged me.  When "having a moment",  I can just read some of my hand picked inspiring verses to be feel nourished again. I call it "My book of God hugs to give me peace, nourish my soul, and bring me joy". 

Books or magazines - I had several friends send me books that would entertain, support my curiosity about this new diagnosis, and provide spiritual guidance in this new journey.

Binder - Someone new comes in every hour and gives you a business card or they hand you a stack of information about the 5 new medications they will be giving that day.   This gave me a place to organize everything and write down my questions.    

Paper plates, cups, utensils - the last thing I wanted to do when I went home was to wash dishes.  Yep, Tricia hooked me up again!   This was such a great idea and help to us without having to worry about washing dishes. 

Comforts of home while in a hospital room:

Water filter pitcher - the tap water out of the ice machine tastes bad, so this will help out

Tape- cover lights to hide unnecessary light from the hallway or machine or hold curtains

EMF blanket - baby blanket size to cover your child for about $69 on Amazon to ease my mind, pair up with your child's favorite pillow case to dress up the room

Sound machine - to help protect your child's sleep and hide all the talking from the hall in the middle of the night.  I chose Wholetones.

Diffusers - for many reasons, but also to make it not smell like a hospital room

Tea tree wipes - I make these homemade, so I can clean the surfaces when I want to

Flashlight - to do late night reading, go to the bathroom, or keep someone from turning on a bright light during the night


Others things family or friends can do:

Gift card for dinner, another friend gave a card for a meal delivery service that we used while in the hospital still

Frozen dinners dropped off - check about dietary restrictions

Amazon wish list - have mom create a "wish list" under their Amazon account, then wish list, give it a name, then it "public".  Let the child pick out some new games, toys, books and let family and friends pick things off of this list.  Tricia was creative and did this and had the items sent to her house.  When we were discharged, she bought the bag of goodies and backpacks over to ration out each week when we had to return for chemotherapy.   Each bag also came with an inspirational christian card to read.  My girls looked forward to each Monday, because they got a new surprise.  This made chemo days start with a smile for them.   It could also be used for supplies the parents are going to need when they get home to help financially offset some of their out of pocket expenses.

Click list - at our local Kroger and Wal Mart, they offer a click list where I can order everything I typically get and pay for it in advance.  Then any one can go by and they will bring it to their car for them.   A family member picked up our groceries, which helped us out immensely to not have to worry about this. 


Some great ideas from caregivers with more experience on this journey suggested these:  

Glass markers to color the windows

Melissa & Doug reusable stickers - we have lots of these too

Fun pillowcases - I love this idea

Printed photos of family and friends

Shipt membership to get groceries or Target delivered

Fake greenery/succulents to brighten up the room    

Toddler training potty to place on bed instead of dragging IV to bathroom for smaller kids

Extension cords for extra electronics

Extra thermometer - or 2 or 3, for home, hospital, purse

Headphones for phone or watch "grown up" shows

Wall decals - I love this idea to brighten up the room!

Extra pairs of fancy children's underpants

Things to consider later:

Roc Solid Foundation - this is a foundation that offers ready bags for hospital trips and backyard playsets for free!!  Go check out this out.  It could take a couple of months, but what a great way to kids moving and outside playing.

Make a Wish foundation - in the past, they have given special trips, but currently their website states they are on hold for trips, but granting wishes like bedroom makeover, playsets, animal or pets, meeting a celebrity, gaming center, computer and more. 

Gigi's Playhouse - this resource is more specific for Down syndrome and offers lots of class for all ages online, both live and prerecorded to help entertain your child and have fun.

As I mentioned before, we were very blessed to have family, friends, and a community supporting our new journey.  I hope these ideas help others when they so dearly want to do .....something....anything to help out.

Blessings to you all,




Tuesday, November 12, 2019

N-acetylcysteine - stock your medicine cabinet with it?

What is NAC?

NAC is a precursor to the amino acid cysteine. It is an important amino acid, which is a precursor to glutathione, the master antioxidant in your body.  So you can say that N-acetyl cysteine, is a precursor to glutathione. The journal Innovation in Clinical Neuroscience states that glutathione is a necessary antioxidant in the body. This means that N-acetylcysteine helps to reduce conditions related to oxidative stress as well as having a therapeutic effect on the brain.  (source)
  • Powerful antioxidant
  • Provides the building blocks for glutathione
  • May protect the lungs, gut, brain, liver, and kidneys
  • May defend against toxins and pollutants
  • May help with obsessive-compulsive symptoms and addiction
  • May help prevent the flu
  • Biofilm disruptor
  • Potential to improve fertility
  • May help with many chronic health problems
  • Doesn’t taste good and can cause nausea
  • May affect bleeding
  • Many purported benefits are unproven  (source)

How can it help with prevention and/or treatment of influenza or other respiratory illnesses?

I recommend watching this 11 minutes video that shows supporting evidence of NAC decreasing the total numbers of influenza cases, decreasing the severity, and decreasing the frequency and repeat illnesses of the elderly when given 600 mg NAC twice a day for 6 months.   This is not the dose for children.

Since NAC decreases the body’s inflammatory response, it may help prevent the flu or reduce symptoms of a common cold. In one study of 262 older people, NAC cut the risk of catching the flu by 54%. It could be especially helpful in the winter months when the flu season takes a hold [40].
NAC is also sometimes added to standard treatments of sinus inflammation and infections [41, 42].
In cells, NAC reduced replication of the flu virus. If the virus can’t replicate quickly, it’s easier to fight it off [43].  (Source)

A well known medication called MucoMist can be inhaled version of NAC.  It is typically given to patients who overdose on Tylenol (acetaminophen)  to treat the oncoming liver damage and to people with Cystic Fibrosis.   It decreases the viscosity or thins their secretions.  

Side effects?   

It can thin the secretions greatly, which will increase the volume of liquid secretions.  This can be an issue with children with DS, who may already have aspiration concerns.     Next, as mentioned in the video, it can lower homocysteine levels.  This is great for those with cardiovascular issues, but children and adults with DS already have a low homocysteine to begin with, so maybe this is for those times of acute illness as a temporary measure. 

Also noted addressing seizures:   Acetyl-L-carnitine At least in eyes, it appears that acetyl-L-carnitine may have antiglycation abilities (55). Hendlor and Rorvik report, “”Acetyl-L-carnitine has recently demonstrated some efficacy as a possible neuroprotective agent for strokes, Alzheimer’s disease, Down’s syndrome and for the management of various neuropathies…recent studies show beneficial effects in Alzheimer’s disease. Younger patients seem to benefit most” (55). However, some few with seizure disorders have reported increases in seizure frequency or severity on acetyl-L-carnitine (54). As the DS population is much more inclined towards seizure disorders than the general public (56), caution would seem to be advisable regarding using acetyl-L-carnitine to attempt to prevent glycation. (source)

Here on the Got Down Syndrome blog post, they also express concerns about NAC increasing intestinal permeability, so again, it doesn't seem like it is supported for long term use in those with DS.  

The winter months are upon us, which means more time spent indoors.  This contributes to greater spread of respiratory illnesses among both children and adults at work and school.  It only takes one person in your family to catch it and "share" it with the entire family due to close proximity.   You also can't turn on the television right now without mention of the influenza virus and the "flu shot".  This is a supplement that deserves your consideration when exposed to acute respiratory illnesses, and for the hard working moms and dads to potentially help them recover quicker, ,and possibly for our children for a temporary amount of time, to potentially help them in their battles against the common cold, influenza, or other respiratory illnesses.  

Please take this information as a launching point to do your own further research.  Then I highly recommend discussing with your physician to see if this information can help your family.    As always, I am not diagnosing, treating, or trying to cure any disease or medical condition with this information.   


Friday, November 1, 2019

Gut, Respiratory, Allergies, Immune system, & more. Could colostrum help?

Does someone in your family have frequent respiratory illnesses, allergies, gut or bowel issues, autoimmune conditions, altered glucose levels, immunodeficiency, low IgA levels, diarrhea, skin disorders, inflammation? 

(picture source and great article     )

We all want to find ways to help our families be healthier, stronger, and more resistant to viruses and bacteria.  I am a retired Physicians Assistant, meaning I now dedicate all my time to homeschooling, working on our farm, and researching how I can help my family in the most natural way possible.  I have two daughters, one is 8 years old and happens to have Down syndrome (DS).  Children with DS can have "weaker", more susceptible immune systems.  The average cold can be brutal on their system, and we have had known many who endured a hospitalization from it.  I personally know many adults and children who have an IgA deficiency, which allows them to "catch" almost every cold/respiratory virus they are exposed to.  

First, I recommend reading some of my previous posts about how to clean up your lifestyle and diet since there is no "magic pill".   These posts will give you a lot of information you need outside of today's information:

As always, I must state I am not giving anyone medical advice, nor attempting to diagnose, treat, or cure any illness or disease. I am not stating there is a "miracle cure" for anything.  I am just providing information for you to take to your doctor and discuss if it is appropriate for your child and your family.   Please do additional research and make an educated and informed decision. 

This is a lengthy post, because I feel it is important to understand the what, how, and why.   I sincerely believe there will be areas of relevance for everybody such as gastric inflammation from NSAID use, infectious diarrhea, combating C Diff, helping to prevent or decrease the duration of respiratory illnesses, helping with increased intestinal permeability (aka leaky gut), allergies, diabetes, athletic performance, potentially helping with cancer, and providing support to boost the immune system.  Keep reading to see the research studies that make associations and claims about this conditions. 

  1.  An overview of the immune system.
  2. What is colostrum and transfer factors?
  3. How can this supplement potentially help my family's immune system and health?
  4. Side effects.
  5. Dosages.
  6. Where can I find these products?

(If you are overwhelmed with too much information, skip down to #4 section for supporting research and see if this applies to you..)


This information is taken from the Book by Dr Aaron White

It is the job of the immune system to protect the body from outside microbial threats, like bacteria, viruses, parasites, and fungi, and to quickly get rid of body cells that become cancerous or damaged in other ways.  It runs 24 hours a day, and is amazingly complex.   Let's begin by looking at various cell types in the immune system. 

White cells (leukocytes) -  Lymphocytes and Phagocytes

Lymphocytes - born in the bone marrow.  Always on the look out for infection or cells that have died or become cancerous.  Some are called B-cells and T-cells, and they look for self vs non self cells based on the presence of antigens.  B cells see an antigen and generate an antibody for it. Antibodies belong to a family of proteins called immunoglobulins (Ig).  Antibodies can incapacitate the pathogen and/or mark them for destruction.  B cells can only produce antibodies that recognize one antigen.  So the immune system has to produce thousands of different types of B cells for each specific threat. Sometimes the threat may be dust, pollen, pet dander and symptoms of allergies can occur.  They are also responsible for autoantibodies that stick to proteins of healthy cells creating autoimmune conditions.  

T cells are lymphocytes that mature in the thymus.  (NOTE THAT THE THYMUS IS TYPICALLY REMOVED IN THE 50% OF CHILDREN WITH DS WHO REQUIRE HEART SURGERY BY 4 MONTHS OLD DUE TO THE PROXIMITY TO THE HEART).  Three types of T cells to mention here are CD8, Cytotoxic T cells, CD4+ Helper T cells, and Suppressor T cells.  Cytotoxic T cells accurately target infected cells.  Helper T cells communicate with other immune cells to initiate and coordinate further attacks.  Suppressor T cells produce signals turning off the immune response to calm the immune system once the threat has passed.  Other lymphocytes called Natural Killer cells immediately spot intruders based on the absence of molecules normally expressed by healthy self cells. They destroy first without calling for back up.  

Phagocytes - larger than lymphocytes and can literally devour potential threats.  Then they present the antigen on their cell surface, migrate to the lymph node and present it to the lymphocytes (B & T cells).  Macrophages are phagocytes positioned around the body where microbes might enter such as the digestive tract, lungs, and mucous membranes. Macrophages can only alert T cells about familiar pathogens though. Dendritic cells are phagocytes that can detect newly encourated microbes and inform the B cells and T cells.  

Granulocytes contain granules that can destroy microbes when they are injected into or sprayed onto potential threats.  One type is mast cells, which play a part in seasonal allergies.  

Cells in the immune system communicate with each other by producing and releasing a variety of proteins known as cytokines.   Chemokines trigger inflammation and attract other immune cells to the area.   Interleukins trigger the immune system to produce additional immune cells.   Certain factors represent a unique messenger used for cell to cell communication within the immune system, like a cross between interleukins and antibodies and also binding to antigens like antibodies do.  They seem to facilitate the work of the Helper and Cytotoxic T Cells by attaching to antigens on infected self cells and flagging them for destruction. 

Innate immunity consists of phagocytes, dendrites, Natural Killer cells and is unchangable.  They devour and kill foreighn objects of all types and some present portions of the object they eat to immunature T cells.  This activates the next line of defense, known as the adaptive immune response.   Adaptive immunity is the process by which the body learns about and catalogues new foreign objects.  

Within the adaptive immunity, there is antibody-mediated and cell-mediated immunity.  Antibody mediated immunity is aimed at protecting the body from viruses and pathogens found floating freely in the blood and lymph.  It occurs when B-cells learn about an antigen and create antibodies to it.  The antibodies cling to the antigen and disable it or flag it for destruction.  Cell-mediated immunity is aimed at protecting the body from pathogens like bacteria and virus that invade healthy cells, such as when cytotoxic T cells destroy infected cells.  


Colostrum is the thin fluid produced by breastfeeding mothers. It is produced in abundance during the very first few milkings, and with each milking, less is produced. Colostrum introduces immunoglobulins from the mother to the infant and turns on the child's immune system. Colostrum has incredible immune-balancing benefits.

Colostrum contains a rich array of nutrients, including growth factors, lipidic and glucidic factors, oligosaccharides, antimicrobials, cytokines and nucleosides. This substance introduces the newborn to over 95 different compounds that balance and stabilize the immune system. It also brings in eight growth factors that promote normal cell growth, DNA synthesis, fat utilization and increased mental acuity.

Bovine colostrum has an identical structure to the natural colostrum produced by humans.(Reference)

Also noted from healthline . Colostrum in particular, is higher in protein, fat, carbs, magnesium, B vitamins, and vitamins A, C, and E than cow’s milk. While colostrum is rich in macronutrients, vitamins, and minerals, its claimed health benefits are mostly linked to specific protein compounds, which include:

  • Lactoferrin. Lactoferrin is a protein involved in your body’s immune response to infections, including those caused by bacteria and viruses
  • Growth factors. Growth factors are hormones that stimulate growth. Bovine colostrum is especially high in two protein-based hormones, insulin-like growth factors 1 and 2, or IGF-1 and IGF-2
  • Antibodies. Antibodies are proteins, also known as immunoglobulins, used by your immune system to fight bacteria and viruses. Bovine colostrum is rich in the antibodies IgA, IgG, and IgM/

Historically colostrum has been used for various illnesses in India as well as abroad for thousands of years. Ayurvedic physicians of India have used bovine colostrum for both medicinal and spiritual purposes since cows were first domesticated.

By the late 18th century, Western medicine started to take an interest in colostrum and study it for its potential health benefits. As a consequence, it was prescribed for many conditions, including immune system enhancement.  Interestingly, until the development of penicillin and other artificial antibiotics in the 20th century, colostrum was commonly used for fighting bacterial infections. Bovine colostrum (BC), which can be obtained in large quantities, has been found to be almost identical to human colostrum in terms of its beneficial components. It has also been found to be equally useful for many mammal species, and produces no side-effects.



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Immunological mechanisms of bovine immunoglobulins. Bovine immunoglobulins can modify innate as well as adaptive immunity. By binding directly to pathogens, bovine immunoglobulins can bind to FcγR bearing innate immune cells, leading to phagocytosis and killing. In some cases, as for RSV, bovine IgG may also fully neutralize human pathogens as demonstrated for RSV in vitro (). Other mechanisms of pathogen elimination may be complement mediated pore formation and killing, and ADCC. On the other hand, as bovine IgG-pathogen immune complexes bind to FcγR, receptor mediated uptake and antigen processing is enhanced, resulting in increased T, and ultimately B-cell responses to the pathogens.


The remarkable health benefits of colostrum

Gut health: 
Colostrum is the most prolific substance for boosting sIgA levels in the gut. This provides a balancing effect on the immune system by reducing inflammatory cytokines and pathogenic species in the gut. Colostrum also helps provide raw materials to help repair a damaged gut lining. The intestinal membrane replaces cells every three days, and colostrum supplementation can help heal intestinal problems such as leaky gut syndrome and other permeability issues naturally.

Colostrum provides over 100 times the amount of immunoglobulins as regular milk. Colostrum is also rich in transfer factors that educate and modulate the immune system and successfully teach it to recognize specific antigens. These transfer factors also help coordinate the immune system to be able to recognize the difference between normal tissue and pathological microbes or abnormal tissue growth. These important transfer factors include hydrogen peroxide and immunoglobin G (IgG).

Various factors from colostrum are able to boost natural killer cell (NK) activity and calm a hyperactive immune system through activating suppressor T cells. This improves the intelligence of the immune system and allows it to function with greater efficiency. Certain factors act as a catalytic memory agent for the immune system to alert naive immune cells of an impending danger.

How to Improve Your Immune Function by Boosting Natural Killer Cells  -  according to Dr Mercola, colostrum can help protect and/or prevent the flu.  


In a 2012 study on mice, oral administration of skimmed and concentrated bovine late colostrum was shown to activate the immune system and protect against influenza infection by boosting NK cell activity.  Another 2014 animal study concluded that, "Colostrum supplementation enhanced NK cell cytotoxicity and improved the immune response to primary influenza virus infection in mice." Colostrum-supplemented mice that did contract the flu also had less severe infection and a lower viral burden in the lungs compared to controls.  An earlier study,21 published in 2007, found treatment with oral colostrum for two months prevented influenza infection three times more effectively than influenza vaccination. According to the authors, "Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least three times more effective than vaccination to prevent flu and is very cost-effective …"

6 Ways Colostrum Benefits You (source Dr Mercola here)

  • Colostrum is a nutrient contained in the breast milk of nursing mammals.
  • This same serum which is necessary for survival in mammals has been shown to have an extraordinary effect on human immunity and the ability to fight cancer.
  • Lactoferrin, a compound contained in colostrum, is a protein required for the metabolism of iron. Organs and cells in the body have receptors for this protein to bind to and inhibit autoimmune responses and inflammation triggered by problems like leaky gut.
  • Colostrum is associated with the reduced frequency from infection of the following bacteria: Acinetobacter baumanii, Pseudomonas aeruginosa, E. coli, and Salmonella.
  • Bovine colostrum (from cows) activates the production of GcMAF in the human body. GcMAF repairs tissue from damage, and supports the immune system in preventing infection, including the growth and spread of cancer.
  • Encouraging clinical results show that the lactoferrin in bovine colostrum activates cytokines, cell proliferation, and boosts detoxification in humans.

Abstracts from PUBMED:  Click on title to read entire article.  (You may have to further click on the full text or article downloaded below the abstract to read the entire article).   I am not making medical claims to diagnose, treat, or cure any medical condition or illness.  This information is taken from research articles that discuss the various areas that have been studied.

Bovine colostrums: a review of clinical uses  

Bovine colostrums are also rich in oligosaccharides, antimicrobials, and immune-regulating factors. Available evidence suggests a beneficial effect of supplementation of bovine colostrums in improving body composition, aspects of athletic performance, diarrhea in persons with immune-deficiency syndromes, NSAID-induced gastrointestinal disturbances, and aspects of the acute phase response that occurs secondary to surgery. Specific hyperimmune bovine colostrums, produced to have high neutralizing titer activity against Cryptosporidia, H. pylori, measles, rotavirus, and Shigella sp., appear to have clinical utility in conditions associated with these infectious organisms.


Bovine colostrum in those with immunodefiency.

Gastrointestinal and respiratory infections are the causes of recurrent morbidity and significant mortality among children in developing countries. IgA is important in protecting the surface tracts like digestive and respiratory tracts and IgA deficiency, even though often transient, is the most common immunodeficiency(1). The use of bovine colostrum rich in IgA is being advised in children for prevention and treatment of various conditions. The rationale behind this is the fact that secretory IgA (SIgA) can resist proteolytic degradation and can survive in the harsh environments of digestive and respiratory tracts. As it is abundant in secretions like tears, saliva and mucosal linings, it is also the first antibody to come in contact with different antigens. Bovine and human SIgA is found to be homologous and colostrum have identified as a rich source ofSIgA(2). SIgA is said to act as blocking and neutralizing antibody and also inhibit potential harmful activation of pro-inflammatory B pathway in the epithelium and enhance stromal clearance of antigen-NF that has breached the mucosal barrier. However, in those with IgA deficiency, there may be potential harmful IgG antibodies against cows’ milk and ruminant serum proteins and against IgA. If the anti-IgA antibodies are of the IgE type, there may be fatal anaphylactic reactions after transfusion of   blood and blood products.



The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency.

Immunoglobulin A (IgA)-deficient patients predominantly suffer from respiratory and gastrointestinal infections since secretory IgA has important functions to protect mucosal surfaces.  Thirty-one IgA-deficient children with viral URI infections were included in this double-blind, placebo-controlled study, and randomly oral bovine colostrum or placebo was given three times a day for 1 week. 
The bovine colostrum group had a lower infection severity score than the placebo group after 1 week (respectively 0.81±0.83, 3.00±1.85; P=0.000), but there was no difference between the salivary IgA levels of the groups

Conclusion:  This is the first study to evaluate the effect of bovine colostrum in IgA deficient children, and no adverse effects were observed.  However, further studies are needed to confirm the efficacy and safety of bovine colostrum in IgA deficient patients.

The effect of bovine colostrum supplementation on salivary IgA in distance runners.

Secretory IgA in saliva (s-IgA) is a potential mucosal immune correlate of upper respiratory tract infection (URTI) status. Nutritional supplements may improve mucosal immunity, and could be beneficial to athletes who are at increased risk of URTI. In this study, 35 distance runners (15 female, 20 male, age 35 to 58 y) consumed a supplement of either bovine colostrum or placebo for 12 wk. Saliva samples were taken prior to training at baseline, monthly during supplementation, and 2 wk post supplementation. Median levels of s-IgA increased by 79% in the colostrum group after 12 wk intervention, and the time-dependent change from baseline value was significant (P = 0.0291). This significance was still apparent after adjusting for training volume and self-reporting of upper respiratory symptoms. This study has demonstrated increased s-IgA levels among a cohort of athletes following colostrum supplementation.


Health factors in colostrum:

Colostrum is thick lemon yellow mammary secretion and is rich in proteins. This lasts for 2-4 days after the lactation has started. This is the source of fats, proteins, sugars and micronutrients in the form of vitamins and minerals. This is very rich source of secretory IgA to give protection to gastrointestinal tract (GIT) from various infections in the new born. Certain maternal conditions like eclampsia, diabetes and anemia can affect the composition of colostrum. Colostrum has been used for various illnesses in India for thousands of years. The medical importance was described in ancient medicine ayurveda. In U.S. colostrum was in use for its anti-bacterial activity before the discovery of antibiotics. There are ninety known components in the colostrum. There are two primary components of colostrum : immune factors and growth factors. Colostrum also contains vitamins, minerals and amino acids according to need of neonates.



(a) Specific Antibodies. The immune factors obtained from the mother have shown to fight to against viruses, bacteria, yeast and fungus. There are around 20 specific antibodies in the colostrum to fight microbes like E.coli, Salmonella, Rotavirus, Candida, Streptococcus, Styphylococcus, Cryptosporidium, H.pylori etc. 3,4,6,7 There is adequate transfer of passive immunity against diarrhea.

(b) Immunoglobulins - Immunoglobulins are superior in defense in both treatment and prevention of viral infections, bacterial infections, allergies, yeast and fungus. 6 There are five types of immunoglobulins IgA, IgD, IgE, IgG and IgM. Bovine colostrum contains 8%-25%, IgG whereas human colostrum contains 2% IgG. These are protein molecules, saline soluble amino acids which have important role in the body to fight against infections. IgA : operates in tears ,saliva and blood (secretory IgA in the gut) IgD : anti-viral IgE : anti-viral IgM : anti-bacterial IgG : abundant, in lymph and blood, and neutralizes toxins. 

 (c) Prolin Rich Polypeptide (PRP): PRP has been shown to stimulate the thymus to regulate the immune system in the body. PRP stimulates the weakened immune system and also stabilizes hyperactive immune system due to autoimmune diseases and allergies in the body.

(d) Lactoferrin : This is an iron binding protein that plays important role against cancer cells and also has anti- viral and anti-bacterial properties and anti inflammatory properties. Lactoferrin can prevent reproduction of bacteria and releases iron for the red blood cells. Lactoferrin receptors have been identified on the immune cells and in involved in release of cytokines. Lactoferrin has been implicated in treatment of diseases like cancer, HIV, herpes, chronic fatigue, candidiasis and other infections. 

(e) Cytokines : These are the interleukines. They regulate duration and intensity of immune responses. They boost T cells activity and have antiviral and anti- tumor activity. Interleukine-10 is having the anti- inflammatory activity in arthritis and during injury. 

(f)  Lymphokines:  These are the peptides involved in mediating the immune response.

(g) Oligopolysaccharides and Glycoconjugate Sugars: They attract and bind to pathogenic bacteria and prevent their entery in the mucosal lining. They block the entry of Salmonella, Cryptosporidium and Clostridia in leaky gut syndrome? 

(h) Glycoproteins and Trypsin Inhibitors: They inhibit the breakdown of colostrum in the gut, hence it can have its effect in the GI tract. Colostrum inhibits the H.pylori in stomach, so anti-ulcer activity. They protect the immune and growth factors in GI tract. 

(i) Lysozyme : This is an acid resistant hydrolyzing agent that is capable of destroying bacteria and viruses on contact. This is being added to commercial baby food. 

(j) Leucocytes : They stimulate interferon production and slow down the viral reproduction. Interferon also inhibits cellular wall penetration. 

(k) Lactoperoxidase-thiocynate, Peroxidase and Xanthine Oxidase Enzymes: They oxidize bacteria by generating the release of hydrogen peroxide. Lactalbumins: Lactalbumins are active against many form of cancers and viruses. Lactalbumins also raise the serotonin levels, decrease the cartisol levels and improve the mood under stress. 


Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children.

BACKGROUND:   Bovine colostrum (BC) has direct antimicrobial and endotoxin-neutralizing effects throughout the alimentary tract, as well as other bioactivities that suppress gut inflammation and promote mucosal integrity and tissue repair under various conditions related to tissue injury. The precise role of BC in respiratory and gastrointestinal (GI) infections in children is not well defined. The aim of this study was to evaluate the efficacy and tolerability of BC administration in preventing recurrent upper respiratory tract infections (URTI) and diarrhea in children.

METHODS: One hundred sixty children (aged 1-6 years) having recurrent episodes of URTI or diarrhea received BC for 4 weeks. The number of episodes of URTI, diarrhea, and frequency of hospitalization required for URTI and diarrhea occurring during the study period were assessed at weeks 8 and 24.   RESULTS:  From a total number of 160 children, 81 patients (50.63%) were males. The mean age (± SD) was 3.65 (± 2.01) years. The mean (± SD) total number of infections was significantly decreased after BC therapy from 8.6 ± 5.1 at baseline to 5.5 ± 1.2 after 2 months (P < 0.001) and to 5.7 ± 1.6 after 6 months (P < 0.001). The mean (± SD) total number of URTI (P < 0.0001), number of episodes of diarrhea (P < 0.001), and number of hospital admissions (P < 0.001) were significantly decreased after BC therapy.

CONCLUSION:  BC is effective in the prophylaxis of recurrent URTI and diarrhea as it reduces the number of episodes and the hospitalization due to these infections. Results of this study suggest that BC could be provided as a therapeutic option for children with recurrent URTI and diarrhea.

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG (bovine IgG) can be recovered from feces, ranging from very low levels up to 50% of the ingested IgG that has passed through the gastrointestinal tract. In infants the recovered levels are higher than in adults most likely due to differences in stomach and intestinal conditions such as pH. This indicates that bovine IgG can be functionally active throughout the gastrointestinal tract. Indeed, a large number of studies in infants and adults have shown that bovine IgG (or colostrum as a rich source thereof) can prevent gastrointestinal tract infections, upper respiratory tract infections, and LPS-induced inflammation. 
Mechanistically, bovine IgG binds to many human pathogens and allergens, can neutralize experimental infection of human cells, and limits gastrointestinal inflammation. Furthermore, bovine IgG binds to human Fc receptors which, enhances phagocytosis, killing of bacteria and antigen presentation and bovine IgG supports gastrointestinal barrier function in in vitro models. These mechanisms are becoming more and more established and explain why bovine IgG can have immunological effects in vivo. The inclusion of oral bovine immunoglobulins in specialized dairy products and infant nutrition may therefore be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients.


Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs.

Only few hours of formula feeding may induce pro-inflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs.

RESULTS:NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine.

Conclusions:  Bovine colostrum restores intestinal function after initial formula induced inflammation in preterm pigs.  Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parental nutrition (TPN) to enteral nutrition, when human milk is unavailable. 

Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones.

Bovine colostrum (BC) has been reported to enhance immune function, reduce fat accumulation and facilitate the movement of glucose to the muscle. However, very few attempts have been made to examine its anti-diabetic effects in diabetes patients. The aim of this study was to evaluate whether BC decreases blood glucose, as well as cholesterol, triglyceride (TG) and ketones levels, which can be elevated by obesity and stress in Type 2 diabetic patients. Sixteen patients (men=8, women=8) with Type 2 diabetes were randomized into the study. Each ingested 5 g of BC on an empty stomach every morning and night for 4 weeks. Blood glucose, ketones (β-hydroxybutyric acid), total cholesterol and TGs were measured every week. In both the men and women, blood glucose levels at 2 and 8 h postprandial decreased continually during the experimental period. The rate of decrease in blood glucose at 8 h postprandial was not different between the men and women, but was higher in the women (14.25±2.66) than in the men (10.96±1.82%) at 2 h postprandial. Total cholesterol and TG levels decreased significantly in both the men and women after 4 weeks. Also, β-hydroxybutyric acid level decreased with BC ingestion, but this was not significant. These results suggest that BC can decrease levels of blood glucose and ketones, as well as reduce cholesterol and TGs, all of which may cause complications in Type 2 diabetic patients.

The effectiveness of oral goat colostrum in the treatment of patients with type 2 diabetes mellitus: our preliminary experience.

INTRODUCTION:The properties of colostrum were recognized and investigated more thoroughly in the first half of the eighties, when the immune factors and growth factors it contains were pointed out. Numerous studies show that the administration of colostrum benefits the subjects with type 2 diabetes mellitus as it gradually regulates appetite, improves utilization of nutrients, especially glucose, and leads to a significant decrease in body fat.

MATERIALS AND METHODS:The following study is aimed at verifying a possible reduction in the use of insulin in 27 subjects with type 2 diabetes, treated with goat colostrum in the form gastro-resistant tablets of 300 mg (4/die).RESULTS: In subjects with type 2 diabetes treated with insulin, the administration of colostrum has obtained a significant reduction of insulin dosage and normalization of blood glucose levels.

CONCLUSIONS:The effects of colostrum are presumably linked to increased levels of IGF-1 that improves the utilization of glucose, stimulates glycogen and protein synthesis.



A study published in the April 2017 journal Nutrients tested bovine colostrum on athletes to see if it helped with leaky gut troubles. The study was small, with only 16 participants, but the authors found that it helped. They suggested that not only could athletes benefit from colostrum supplements, but that people hoping to restore a healthy gut balance after using NSAIDs could benefit.

A review of bovine colostrum studies and clinical trials in the June 2016 edition of the journal Frontiers in Bioscience _concluded that colostrum offers good treatment options for gastrointestinal troubles. The authors noted that more studies are needed and also stated that colostrum supplements could be combined with synthetic drugs to treat many stomach disorders. 

More support for bovine colostrum comes from an article in the September 2015 edition of the Journal of Complementary and Integrative Medicine. The authors noted that bovine colostrum is, for the most part, considered safe and is well-tolerated.


Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection.

Non-immune colostrum-treated piglets developed moderate to severe diarrhea and colitis. In contrast, HBC-treated piglets had mild or no diarrhea and mild or no colitis. HBC provides an oral, cost-effective, and safe alternative to antibiotic therapy for CDI. By preserving intestinal microbiota, HBC may be more efficacious than antibiotics. Additional studies are warranted to establish HBC as a viable immunotherapeutic agent for human use against CDI.


Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4.

Colostrum-supplemented mice demonstrated less reduction in body weight after influenza infection, indicating a less severe infection, increased NK cell cytotoxicity, and less virus burden in the lungs compared with controls. Colostrum supplementation enhanced NK cell cytotoxicity and improved the immune response to primary influenza virus infection in mice. 


Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study.

 The aim of this study was to evaluate the efficacy of colostrum (ARD Colostrum) in association with the immunomodulator Bifivir in the prevention of flu episodes compared with anti-flu vaccination. The registry groups included no prevention, vaccination, vaccination+immunomodulators, and immunomodulators only. Groups were comparable for age and sex distribution. In the group without prevention there were 8 major episodes and 12 minor episodes out of 34 subjects; in the vaccination group the respective figures were 8-13/38; in the group treated with a combination of vaccination and immunomodulators (ARD Colostrum + Bifivir) the figures were 4-9/33; and in the group treated with immunomodulators only there were 11 viral episodes (3-8) in 36 subjects. The episodes in the vaccination+immunomodulators and immunomodulators only groups were significantly lower compared with the other two groups 


Role of colostrum in gastrointestinal infections.

The main actions include an antibacterial effect and modulation of immune response with the ability to neutralize lipopolysaccharides arising from gram negative bacterial pathogens. It has been found to be effective in infantile hemorrhagic diarrheas, other diarrheas and reduces the likelihood of disease progressing to hemolytic uremic syndrome. It has also been tested in H. pylori infection and diarrhea in immunodeficiency. Side effects of clinical relevance are limited to possible intolerance due to lactose and sensitivity to milk proteins.



Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino.

The efficacy of a 2-month treatment with oral colostrum in the prevention of flu episodes compared with anti-influenza vaccination was evaluated. Groups included healthy subjects without prophylaxis and those receiving both vaccination and colostrum. After 3 months of follow-up, the number of days with flu was 3 times higher in the non-colostrum subjects. The colostrum group had 13 episodes versus 14 in the colostrum + vaccination group, 41 in the group without prophylaxis, and 57 in nontreated subjects. Part 2 of the study had a similar protocol with 65 very high-risk cardiovascular subjects, all of whom had prophylaxis. The incidence of complications and hospital admission was higher in the group that received only a vaccination compared with the colostrum groups. Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective.



Use of immunoglobulin enriched bovine colostrum against oral challenge with enterohaemorrhagic Escherichia coli O157:H7 in mice.   

In mice pretreated with streptomycin, EHEC O157:H7 maintained stable levels of bacterial colonization in the intestines for the 3-week experimental time period. Oral administration of colostrum resulted in rapid decrease in the bacteria numbers compared with administration of skim-milk. Colostrum showed no direct in vitro bactericidal properties against either EHEC O157:H7. When sections prepared from cecum walls of streptomycin-pretreated mice were incubated in vitro with EHEC O157:H7, the colostrum significantly prevented the attachment of the organisms to the sections when compared with skim-milk. These results indicate that oral administration of bovine colostrum effectively protects mice against food-borne infections by inhibiting bacterial attachment to the intestinal mucous membrane, colonization and growth in the intestinal tract.


A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells. 

Results revealed that the expression of a significant number of genes involved in cell migration, adhesion and proliferation was indeed affected in colostrum whey-treated cells. In conclusion, colostrum specific bioactive content could be beneficial for intestinal epithelial cell homoeostasis by controlling biological processes implicated in wound healing through a precise gene expression program.


The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes.

Heavy exercise causes gut symptoms and, in extreme cases, "heat stroke" partially due to increased intestinal permeability of luminal toxins. We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects.Colostrum increased HSP70 expression at both 37 and 39°C (P < 0.001) and was truncated by addition of an EGF receptor-neutralizing antibody. Temperature-induced increase in Baxα and reduction in Bcl-2 was partially reversed by presence of colostrum. Colostrum may have value in enhancing athletic performance and preventing heat stroke.


Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.

Gut injuries were induced by administration of a single dose of diclofenac.   Diclofenac caused a marked increase in the intestinal permeability, enteric bacterial numbers and intestinal villous damage, and enteric protein and albumin loss. Combined administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.


Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Bovine colostrum is a cheap, readily available source of growth factors.  For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm on day 5 colostrum was co-administeredIn patients taking long-term NSAID treatment, initial permeability ratios were low (0.13+/-0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans. gastrointestinal injury in rats and mice.  

Bovine colostrum is a health food supplement which prevents NSAID induced gut damage.

Pretreatment with 0.5 or 1 ml colostral preparation reduced gastric injury by 30% and 60% respectively in rats. A milk preparation was much less efficacious. Recombinant transforming growth factor beta added at a dose similar to that found in the colostrum preparation (12.5 ng/rat), reduced injury by about 60%. Addition of colostrum to drinking water (10% vol/vol) prevented villus shortening in the mouse model of small intestinal injury. Addition of milk preparation was ineffective. Colostrum increased proliferation and cell migration of RIE-1 and HT-29 cells. These effects were mainly due to constituents of the colostrum with molecular weights greater than 30 kDa.

CONCLUSIONS:Bovine colostrum could provide a novel, inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut and may also be of value for the treatment of other ulcerative conditions of the bowel.

A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans.

RESULTS:  A single dose of CLMWF, when compared to placebo, resulted in rapid increase in phagocytic activity of monocytes at 1 hr.CONCLUSION:  The increased phagocytic activity and rapid transient changes in NK cell numbers suggest that upon consumption, interaction of CLMWF with immune cells in the gut mucosa triggers immediate events with systemic consequences.



Antitumor and chemopreventive activity of lactoferrin

 Lactoferrin, an evolutionary old protein of the transferrin family, is among the proteins constituting the system of innate immunity; its action, however, also extends to the regulation of acquired immunity and other immunological phenomena. The actions of LF, confirmed in numerous in vitro and in vivo models, include participation in iron homeostasis, immunoregulatory properties, anti-inflammatory, anti-tumor, and analgesic actions, regulation of bone metabolism, participation in embryonic development, reproductive functions, and others. Studies showed that LF elevates the number and increases the activity of T and B lymphocytes and NK cells, stimulates the release of a number of cytokines (IL-1, -6, -8, -18, IFN-gamma, TNF alpha), increases phagocytic activity and cytotoxicity of monocytes/macrophages, accelerates the maturation of T and B cells, and elevates the expression of several types of cellular receptors, such as CD4, zeta chain of the CD3 complex, LFA-1, CD11, ICAM-1, and selectin P. Apart from its immunomodulatory properties, LF exhibits direct anti-tumor actions, such as lytic, pro-apoptotic, anti-proliferative, anti-angiogenic, anti-oxidant activity and the chelation of iron ions. LF also possesses chemo-preventive properties, regulates the activity of phase I and II enzymes participating in the activation and detoxification of carcinogens, and regulates the composition of the intestinal microflora. In this way it prevents the generation of tumors and their development at early stages of carcinogenesis.


Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells.

Lactoferrin is an iron-binding glycoprotein implicated in particular in the control of immune functions and cell proliferation. We have investigated its involvement, at inflammatory concentrations, in cancer progression. We report that lactoferrin has a significant effect on natural killer (NK) cell cytotoxicity against haematopoietic and breast epithelial cell lines. Lactoferrin increases cytolysis at a low concentration (10 micrograms/ml) while at a high concentration (100 micrograms/ml) it modulates cytolysis depending on the target cell phenotype. By pre-treatment of either NK cells or target cells with lactoferrin, we have demonstrated that the lactoferrin effect is due both to a modulation of NK cell cytotoxicity and the target cell sensitivity to lysis. Lactoferrin binds to 91% of the naturally heterogeneous CD56dim/bright NK cell population and increases the NK cell cytotoxic activity at low concentrations. High concentrations of lactoferrin seem to be toxic for the CD56bright NK cells and decrease NK cell cytotoxicity. Lactoferrin also exerts an effect on target cells depending on the cell phenotype. It does not modify the susceptibility to lysis of haematopoietic cells such as Jurkat and K-562 cells, but does significantly increase that of the breast and colon epithelial cells. We have also demonstrated that lactoferrin inhibits epithelial cell proliferation by blocking the cell cycle progression.

Bovine colostrum supplementation attenuates the decrease of salivary lysozyme and enhances the recovery of neutrophil function after prolonged exercise.

Oral supplementation with bovine colostrum (COL) has been shown to enhance immunity in human subjects. However, there is limited research on the use of bovine COL supplementation to counter exercise-induced immunodepression, as a model of stress-induced immunodepression, and previous research has focused primarily on salivary IgA. The aim of the present study was to determine the effects of bovine COL supplementation on exercise-induced changes in innate immunity (neutrophil function and salivary lysozyme) in addition to salivary IgA. Twenty healthy, active men cycled for 2 h at approximately 64 % maximal oxygen uptake after 4 weeks of daily bovine COL (n 10) or placebo (PLA, n 10) supplementation. Blood and saliva samples were obtained before and after supplementation, before and after exercise. Exercise induced significant increases in markers of physiological stress and stress to the immune system (circulating neutrophils, neutrophil:lymphocyte ratio, immature granulocytes, atypical lymphocytes and plasma cortisol), but there were no differences between the COL and PLA groups. Significant group x time interactions (two-way mixed model ANOVA) were observed for neutrophil function (stimulated degranulation) and salivary lysozyme concentration and release (P < 0.05). Significant exercise-induced decreases were observed in these parameters, and bovine COL supplementation either speeded the recovery (neutrophil function) or prevented the decrease (salivary lysozyme) in these measures of innate immunity. These results suggest that 4 weeks of bovine COL supplementation limits the immunodepressive effects induced by an acute prolonged physical stressor, such as exercise, which may confer some benefits to host defense.


Insulin-like growth factor-1 protects against prion peptide-induced cell death in neuronal cells via inhibition of Bax translocation.

 Insulin-like growth factor-1 (IGF-1) is one of the most important components of bovine colostrum. It exhibits antiapoptotic and antioxidative activities. Prion diseases are neurodegenerative disorders caused by cell death through mitochondrial dysfunction and increasing generation of reactive oxygen species (ROS). This study examined the protective effect of IGF-1 on residues 106-126 of the cellular prion protein [PrP (106-126)]-mediated mitochondrial neurotoxicity and oxidative stress. In SH-SY5Y human neuronal cells, treatment with PrP (106-126) decreased the cell viability and IGF-1 pretreatment markedly blocked the PrP (106-126)-induced neuronal cell death. IGF-1 inhibited PrP (106-126)-induced intracellular ROS generation and mitochondrial oxidative stress. In addition, IGF-1 blocked the translocation of the Bax protein to the mitochondria induced by PrP (106-126). These results demonstrate that IGF-1 protects neuronal cells against PrP (106-126)-mediated neurotoxicity through an antioxidative effect and blockage of mitochondrial Bax translocation. The results also suggest that regulation of IGF-1 secretion may have a therapeutic potential in the management of mitochondrial dysfunction and oxidative stress-induced neurodegeneration.


Immunomodulatory effects of lactoferrin

 Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses.


Lactoferrin immune response against pathogens.
Mechanism of action of LfTargetReference
Enhancing of phagocytosisGram-Positive bacteria   S mutans   S epidermidis   S aureus Gram-Negative bacteria:   P aeruginosa   B cepacia   B cenocepacia   Porphyromonas gingivalis Virus:   VSV (Vesicular Stomatitis Virus) Fungi:   Candida spp.   A Fumigatus Parasites:   E histolytica   B caballi   T cruzi,,,,,
Biofilms inhibitionGram-Negative bacteria:   Porphyromonas gingivalis   Prevetella intermedi   P aeruginosa   B cepacia   B cenocepacia   E coli   M bovis Gram-Positive bacteria:   S epidermidis,,,
Positive domain union with negative charges on microorganismsGram-Negative bacteria:   E coli Parasites:   T gondii   E stiedai,
Modification of the interactions of microbes, with the host cells, or with the extracellular matrixGram-Positive bacteria:   B subtilis   K pneumoniae   S mutans Virus:   Rotavirus   Enterovirus,
Inhibits LPS-mediated activationGram-Negative bacteria,,
Induction of apoptosisFungi:   Candida albicans



Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

Several in vitro and animal studies have shown effects of bovine IgG and colostrum in viral respiratory tract infections. Bovine immunoglobulins can bind to—and in vitro even neutralize—RSV, a common childhood pathogen resulting in upper respiratory tract infections in infants especially in the first year of life (). Furthermore, bovine immunoglobulins from non-immunized cows have been shown to be able to bind to human RSV as well as to influenza virus, and are able to prevent the infection of Hep2 cells by human RSV in vitro (). In addition, dietary bovine colostrum could reduce the severity of infection and viral titers in a murine model of RSV infection (). Specificity of the antibodies against respiratory viruses might further enhance efficiency in prevention and/or treatment of disease as was discussed above for gastrointestinal pathogens.

In a follow up study (non-immunized) oral bovine colostrum reduced the severity of influenza infection, by reducing viral load and preventing loss of body-weight (). In addition, splenic NK activity, as well as the production of IgA producing B cells in the small intestine and lungs, was noted in the colostrum group.

 The primary role of immunoglobulins on mucosal surfaces is to bind to pathogens to prevent their entry into the body. This process is termed immune exclusion. During immune exclusion the pathogens as well as the immunoglobulins remain confined to the intestinal lumen and the immunoglobulins prevent adhesion to intestinal epithelium. Hyperimmune bovine immunoglobulins can prevent the adhesion of pathogens to intestinal epithelial cells () and even immunoglobulins from non-immunized cows can prevent adhesion of some pathogens (, ). As an example, the adhesion of Clostridium difficile to human intestinal epithelium cells (Caco-2 cells) was inhibited dose-dependently by normal bovine colostral whey () and spray dried colostrum from normal cows was shown to inhibit the adhesion of several necrotizing enterocolitis-associated pathogens to HT-29 colonic epithelial cells.
At the next level, there are indications that bovine immunoglobulins and colostrum can also support intestinal barrier function. When intestinal barrier function is compromised, bacterial products such as LPS, food allergens, as well as pathogens can passively cross the epithelial layer and cause inflammation and infection in the mucosa. Bovine colostrum can inhibit the NF-κB signaling pathway and induction of pro-inflammatory cytokines in HT29 cells, suggesting colostrum has direct anti-inflammatory effects on intestinal epithelium (). Furthermore, bovine IgG can also have anti-inflammatory effects by preventing translocation of bacterial components across the epithelial layer. This was investigated in a co-culture model of intestinal epithelial C2BBe1 cells and THP-1 cells. In this model bovine serum derived IgG could prevent the translocation of bacterial components over the epithelium, thus preventing inflammatory responses to bacterial ligands in the underlying THP1 cells.


Subject characterisiticsType of studyProduct, dosage, and durationReported outcomeReferences
1–6 year old Egyptian children with recurrent URTI and/or diarrhea (n = 160)open, non-comparativeColostrum, 3 g/day for <2 6="" day="" for="" g="" year="">2 years, 4 weeksLower number of episodes and hospitalizations for URTI (and GITI)


1–8 y old Indian children with recurrent URTI/diarrhea (n = 605)open, non-comparativeColostrum 3 g/day, 12 weeksLower number of episodes and hospitalizations for URTI (and GITI)


3–9 year old healthy japanese children (active n = 103; placebo n = 104)Placebo controlled, randomized, double blindLate colostrum (10% Igs)- vs. semi skimmed milk tablets 0.5 g/day. 9 weeksFrequency and duration of URTI was lower in the treatment group vs. the control group, especially in the 3–6 year old children
3–7 year old Italian children with recurrent URTI (active n = 67; placebo n = 100)Retrospective observational studySinerga (incl. colostrum, incl probiotics) vs. bacterial extracts 1 sachet (a 3 g)/day, 10 days month 1, 20 days months 2,3,4Greater reduction in the frequency of respiratory infections that needed antibiotic therapy in the group of children supplemented with Sinerga than in the group treated with bacterial extracts.
50–60 year old Italian healthy volunteers (n = 41 vs. n = 36 vs. n = 39 vs. n = 23)Randomized studyVaccination ± colostrum product vs. colostrum only vs. no prophylaxis 1 tablet a 400 mg (25-40% Ig)/day, 8 weeksNumber of days with flu was 3 times higher in the non-colostrum compare to the colostrum treated group (colostrum+vacc 14 vs. vacc only 57 vs. colostrum only 13 episodes vs. non-treated 41)

60–70 year old Italian elderly people with high risk for influenza (heart/lung problems) (n = 21 vs. n = 20 vs. n = 19)Randomized studyvaccination ± colostrum product vs. colostrum only vs. no prophylaxis 1 tablet a 400 mg (25–40% Ig)/day, 8 weeksThe incidence of complications and hospital admission was higher in the group that received only a vaccination compared with the colostrum groups.


Nutritional roles of lactoferrin.

Ingested lactoferrin has been suggested to exert antibacterial and antiviral activities in the intestine, in part through a direct effect on pathogens, but possibly also affecting mucosal immune function. The latter function is most likely mediated by lactoferrin being taken up by cells via a unique receptor-mediated pathway and affecting gene transcription. Lactoferrin has also been shown to enhance iron status of infants and pregnant women, possibly also via the receptor-mediated pathway. In addition, lactoferrin can stimulate intestinal cell proliferation and differentiation, causing expansion of tissue mass and absorptive capacity. On the contrary, lactoferrin has been shown to inhibit carcinogenesis. Recent findings also suggest that oral lactoferrin treatment may have an anti-inflammatory effect on pregnant women, reducing pregnancy complications.

SUMMARY: Lactoferrin treatment may have beneficial preventive and therapeutic effects on infection, inflammation, and cancer as well as enhancing iron status and growth in vulnerable groups.

Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes

Our study provides evidence which suggests that plain bovine colostrum, which is a natural and relatively inexpensive supplement, can be responsible for the effective reversal of inappropriately increased intestinal permeability. The use of it might benefit many patients, in whom increased intestinal permeability would ultimately result in various pathologies [,,,]. Bovine colostrum might also have a preventive role in healthy people and help to restore gut status after use of antibiotics or NSAIDs, both of which can increase intestinal permeability. Among those who may benefit the most from colostrum supplementation are athletes, who not only present tendency to have increased intestinal permeability, but have also been discovered to have increased risk of developing some of the hypersensitivity-based diseases, including allergies.



Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones.

Bovine colostrum (BC) has been reported to enhance immune function, reduce fat accumulation and facilitate the movement of glucose to the muscle. However, very few attempts have been made to examine its anti-diabetic effects in diabetes patients. The aim of this study was to evaluate whether BC decreases blood glucose, as well as cholesterol, triglyceride (TG) and ketones levels, which can be elevated by obesity and stress in Type 2 diabetic patients. Sixteen patients (men=8, women=8) with Type 2 diabetes were randomized into the study. Each ingested 5 g of BC on an empty stomach every morning and night for 4 weeks. Blood glucose, ketones (beta-hydroxybutyric acid), total cholesterol and TGs were measured every week. In both the men and women, blood glucose levels at 2 and 8 h postprandial decreased continually during the experimental period. The rate of decrease in blood glucose at 8 h postprandial was not different between the men and women, but was higher in the women (14.25+/-2.66) than in the men (10.96+/-1.82%) at 2 h postprandial. Total cholesterol and TG levels decreased significantly in both the men and women after 4 weeks. Also, beta-hydroxybutyric acid level decreased with BC ingestion, but this was not significant. These results suggest that BC can decrease levels of blood glucose and ketones, as well as reduce cholesterol and TGs, all of which may cause complications in Type 2 diabetic patients.







According to the current state of knowledge, colostrum appears to be safe and no contraindications are observed even when administered at high concentrations both in humans and animals (189,190). Some authors have reported lactose intolerance, nausea, flatulence, transient diarrhea and unspecified abdominal discomfort as possible side effects while other studies specifically reported the absence of side effects (83,128,129,165,137,143,189,190). However, further research is required in order to confirm these data, and, more importantly, to evaluate the effects of colostrum when used for a prolonged periods of time and during pregnancy. Milk allergy is the most frequent food allergy in infancy and childhood. Like milk colostrum contains caseins, a-lactalbumin and β-lactoglobulin, and other minor proteins (immunoglobulins, bovine serum albumin) that are deemed to be the main allergens (191). For this reason, colostrum is not recommended for treating individuals who are sensitive to milk proteins.  Again, if you are allergic to cow milk, do not take this product.  You may discuss with you physician alternatives, such as goat colostrum. 

From Livestrong: 
The authors of the Frontiers in Bioscience article said colostrum is safe, even at high dosages, with few side effects. The authors of the Journal of Complementary and Integrative Medicine article said those who are lactose intolerant may have fewer effects from bovine colostrum than from milk.
Still, the Memorial Sloan Kettering Cancer Center advises people who are lactose-intolerant not to take bovine colostrum. Bovine colostrum also contains trace amounts of estrogen, so if you have a hormone-sensitive cancer, you should discuss bovine colostrum with your doctor before taking the supplement.

No transmission of mad cow disease has ever been connected with the dairy industry, either in the U.S. or abroad. To be certain, choose a company that certifies their colostrum to be free of List A diseases like BSE (cause of mad cow disease).  (Ref)

NOTE:  HYPERIMMUNE BOVINE COLOSTRUM:   The FDA approved HIBC under orphan drug status, which grants special status to biological products used to treat rare diseases or conditions. The manufacturing process is as follows:
[HIBC] is produced by cows that have received vaccinations against specific disease-causing organisms. The vaccinations cause the cows to develop antibodies to fight those specific organisms. The antibodies pass into the colostrum. Hyperimmune bovine colostrum has been used in clinical trials for treating AIDS-related diarrhea, diarrhea associated with graft versus host disease following bone marrow transplant, and rotavirus diarrhea in children. 


This was found on webmd.    Please take per label directions or as directed by your physician.   I have read several times to begin slowly, do not begin at full dose or it could cause nausea, flatulence,bloating, or headaches. Also to take an empty stomach when possible. Please stop taking if you experience any unusual symptoms and follow up with your doctor. 

I read several times best preventative results were noted after 8 weeks of use.  

The following doses have been studied in scientific research and seem much higher than you will find in the over the counter capsules, which is typically 1mg (1000 mg) for age 12 and above.  I post these only to show colostrum has been tested at higher doses. 


  • For preventing upper airway infections in people who exercise: 10-20 grams of bovine colostrum daily for 8-12 weeks has been used.
  • For diarrhea in people with HIV: 10-30 grams of bovine colostrum powder has been taken 1-4 times daily for 10-21 days.
  • For the flu (influenza): 400 mg of a defatted freeze-dried bovine colostrum daily for 8 weeks has been used.
  • For infectious diarrhea: 7 grams of bovine colostrum three times daily for 14 days has been used. For preventing infectious diarrhea, 3 grams of bovine colostrum once daily for 4 weeks has been used in children under 1-2 years-old, and 3 grams twice daily for 4 weeks has been used in children 2-6 years-old.
  • For rotaviral diarrhea: 10 grams of bovine colostrum daily for 4 days, or 20-300 mL daily for up to 2 weeks, has been used.


There are many brands found on Amazon, iherb, or at your local health food store. I found most very affordable at $10-$50 a month.   Your health is worth it!  They come in powders, capsules, and chewables.   Look for non GMO sources that have not been given any artificial hormones or antibiotics.  Look for quality sources from happy cows raised in pesticide free pastures.


I hope you have found something in this post useful for you and your family.  There is a lot of information about taking bovine colostrum on the internet.  I highly recommend you use this information as a launching point and continue to learn more through trusted websites and your physician.     I would love to do a follow up with those that try it.   My goal is always to help families learn new ways that may help them to stay healthy.

Blessings  ✟,

Those who do not make time for health, will surely have to make time for illness.